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Disclaimer: Individual results vary. Anti-TNF treatment for the indications below is off-label. Please see the Legal Disclaimer. Maintenance dosing, usually weekly, but sometimes as little as monthly, is necessary for optimal effect. The methods of anti-TNF treatment utilized for these patients are patented inventions of the INR[1].

Rapid improvement in speech following anti-TNF initiation at the INR (2008)*
video length 4:59

Rapid improvement in speech in primary progressive aphasia following perispinal etanercept. For the published results please see Perispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanisms. Edward Tobinick MD. Medscape Journal of Medicine, Neurology and Neurosurgery Clinical Cases 2008 June 10; 10(6):135. This video was included as part of the peer-reviewed, published, scientific article.
The videos above are interviews discussing and documenting the clinical response to initiation of anti-TNF treatment (perispinal etanercept) at the INR. For the published results please see Tobinick E, Gross H, Weinberger A, Cohen H., TNF-alpha Modulation for Treatment of Alzheimer's Disease: A 6-Month Pilot Study MedGenMed 2006; 8(2) :25; Tobinick E., Perispinal etanercept for treatment of Alzheimer's disease, Current Alzheimer Research 2007 Dec; 4(5):550-2; Tobinick E, Gross H., Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease, BMC Neurology 2008; 8:27; and Tobinick E., Perispinal etanercept for neuroinflammatory disorders, Drug Discovery Today 2009 Feb; 14(3-4):168-77.

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Copyright ©2009, the Institute for Neurological Research® (INR®), a private medical group, inc., all rights reserved. [1]U.S. patents 6,982,089 and 7,214,658, and additional issued and pending U.S. and foreign patents. These patents are assigned to TACT IP LLC. Please see the medical and legal disclaimer.

*Perispinal etanercept for Alzheimer's disease and other forms of dementia is a patented, off-label treatment method developed at the INR.
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