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Return to Home PageEdward Tobinick MD
Perispinal etanercept: a new therapeutic paradigm in neurology.
Expert Review of Neurotherapeutics 2010 June 10(6):985-1002. [ link
to abstract and article ].
Edward Tobinick MD
Tumor necrosis factor modulation for treatment of Alzheimer's
disease: rationale and current evidence.
CNS Drugs 2009 September 23(9):713-25. [ link
to abstract and article ].
Edward Tobinick MD
The value of drug repositioning in the current pharmaceutical
market.
Drug News and Perspectives 2009 Mar-Apr 22(2). [ link
to abstract and article ].
Edward Tobinick MD, K Chen, X
Chen
Rapid intracerebroventricular delivery of Cu-DOTA-etanercept
after peripheral administration demonstrated by PET imaging.
BMC Research Notes 2009 Feb 27; 2:28. [ link
to abstract and article ].
Edward Tobinick MD
Perispinal etanercept for neuroinflammatory disorders.
Drug Discovery Today 2009 Feb;14(3-4):168-77. [ link to abstract
and article ]
Edward Tobinick MD
Perispinal etanercept produces rapid improvement in primary
progressive aphasia: Identification of a novel, rapidly reversible
TNF-mediated pathophysiologic mechanism.
Medscape J Med 2008; 10(6):135.
Edward Tobinick MD, Hyman Gross
MD
Rapid improvement in verbal fluency and aphasia following perispinal
etanercept in Alzheimer's disease.
BMC Neurol 2008 Jul 21; 8(1):27. [ link
to abstract and article ].
Edward Tobinick MD
Re: Inflammatory markers and the risk of Alzheimer disease:
the Framingham Study.
Neurology 2008 Apr 1; 70(14):1222-3; author reply 1223.
Edward Tobinick MD
A critique of intradiscal administration for treatment of radiculopathy.
Anesthesiology 2008 Feb; 108(2):334; author reply 335.
Edward Tobinick MD, Hyman Gross
MD
Rapid cognitive improvement in Alzheimer's disease following
perispinal etanercept administration.
J Neuroinflammation 2008 Jan 9; 5(1):2.
Edward Tobinick MD
Perispinal etanercept for treatment of Alzheimer's disease.
Curr Alzheimer Res 2007 Dec; 4(5):550-2. [ link
to abstract and article ]
Edward Tobinick MD
Spinal Delivery of p38: TNF-alpha Inhibitors.
PLoS Med 2006 Nov; 3(11):e511.
Tobinick E, Gross H, Weinberger
A, Cohen H.
TNF-alpha Modulation for Treatment of Alzheimer's Disease:
A 6-Month Pilot Study.
MedGenMed 2006; 8(2):25.
Edward Tobinick MD
The Cerebrospinal Venous System: Anatomy, Physiology, and Clinical
Implications.
MedGenMed 2006; 8(1):53.
Edward Tobinick MD, Susan Davoodifar
MD
Efficacy of etanercept delivered by perispinal administration
for chronic back and/or neck disc-related pain: a study of clinical
observations in 143 patients.
Curr Med Res Opin 2004 Jul; 20(7):1075-85. [ link
to abstract and article ]
Edward Tobinick MD
TNF-alpha inhibition for potential therapeutic modulation of
SARS coronavirus infection.
Curr Med Res Opin 2004 Jan; 20(1):39-40.
Edward Tobinick MD
Targeted etanercept for treatment-refractory pain due to bone
metastasis: two case reports.
Clin Ther 2003 Aug; 25(8):2279-88.
Edward Tobinick MD
Targeted etanercept for discogenic neck pain: uncontrolled,
open-label results in two adults.
Clin Ther 2003 Apr; 25(4):1211-8.
Edward Tobinick MD, Susan Davoodifar
MD
Perispinal TNF-alpha inhibition for discogenic pain.
Swiss Med Wkly 2003 Mar 22; 133(11-12):170-7.
Please click on each of
the images below to download a summary or full-text version of
the article depicted:
The following publications in 2007-8 have
cited scientific publications of Edward Tobinick MD, Director
of the INR®,
including the most recent publication:
Scientific
Articles:
1. Griffin WS. Perispinal etanercept: Potential as an Alzheimer
therapeutic. J Neuroinflammation. 2008 Jan 10;5(1):3. [download free full-text PDF].
2. Misra, Ambikanandan; Jogani, Viral; Jinturkar, Kaustubh; Vyas,
Tushar. Recent Patents Review on Intranasal Administration
for CNS Drug Delivery. Recent Patents on Drug Delivery &
Formulation, Volume 2, Number 1, January 2008 , pp. 25-40(16).
3. Zanella, John M. MS; Burright, Eric N. PhD; Hildebrand, Keith
DVM, PhD; Hobot, Chris BS; Cox, Mark BS; Christoferson, Laura
BS; McKay, William F. MS. Effect of Etanercept, a Tumor Necrosis
Factor-Alpha Inhibitor, on Neuropathic Pain in the Rat Chronic
Constriction Injury Model. Spine 33(3):227-234, February 1,
2008.
4. Sonya Vasto, Giuseppina Candore, Giovanni Duro, Domenico Lio,
Maria Paola Grimaldi, Calogero Caruso. Alzheimer's disease
and genetics of inflammation: a pharmacogenomic vision. Pharmacogenomics
December 2007, Vol. 8, No. 12, Pages 1735-1745.
5. Tweedie D, Sambamurti K, Greig NH. Drug Design & Development
Section, Laboratory of Neurosciences, Intramural Research Program,
National Institute on Aging, National Institutes of Health, Baltimore,
MD 21224, US. TNF-alpha Inhibition as a Treatment Strategy
for Neurodegenerative Disorders: New Drug Candidates and Targets.
Curr Alzheimer Res. 2007 Sep;4(4):375-8.
6. Van Eldik, L. J. Thompson, W. L. Ranaivo, H. R. Behanna, H.
A. Watterson, D. M. Glia Proinflammatory Cytokine Upregulation
as a Therapeutic Target for Neurodegenerative Diseases: Function-Based
and Target-Based Discovery Approaches, International Review
of Neurobiology 2007, 82:278-297.
7. Uceyler N, Sommer C. Cytokine-induced Pain: Basic Science
and Clinical Implications. Reviews in Analgesia 2007;9(2):87-103.
8. Tubbs RS, Hansasuta A, Loukas M, Louis RG, Jr., Shoja MM, Salter
EG, et al. The basilar venous plexus. Clin Anat 2007.
9. Saxena AK, Kumar S. Management strategies for pain in breast
carcinoma patients: current opinions and future perspectives.
Pain Pract 2007;7(2):163-77.
10. Owlia MB, Salimzadeh A, Alishiri G, Haghighi A. Comparison
of two doses of corticosteroid in epidural steroid injection for
lumbar radicular pain. Singapore Med J 2007;48(3):241-5.
11. Munoz L, Ralay Ranaivo H, Roy SM, Hu W, Craft JM, McNamara
LK, et al. A novel p38alpha MAPK inhibitor suppresses brain
proinflammatory cytokine up-regulation and attenuates synaptic
dysfunction and behavioral deficits in an Alzheimer's disease
mouse model. J Neuroinflammation 2007;4(1):21.
12. Hu W, Ranaivo HR, Roy SM, Behanna HA, Wing LK, Munoz L, et
al. Development of a novel therapeutic suppressor of brain
proinflammatory cytokine up-regulation that attenuates synaptic
dysfunction and behavioral deficits. Bioorg Med Chem Lett
2007;17(2):414-8.
13. Le Maitre CL, Hoyland JA, Freemont AJ. Catabolic cytokine
expression in degenerate and herniated human intervertebral discs:
IL-1beta and TNFalpha expression profile. Arthritis Res Ther.
2007 Aug 9;9(4):R77.
14. Kenneth M. Kulmatycki1, Fakhreddin Jamali. Drug Disease
Interactions: Role of Inflammatory Mediators in Pain and Variability
in Analgesic Drug Response. J Pharm Pharm Sci, 10 (4): 554-566,
2007.
15. Schäfers, Maria; Sommer, Claudia. Anticytokine
therapy in neuropathic pain management. Expert Review of Neurotherapeutics,
Volume 7, Number 11, November 2007 , pp. 1613-1627(15).
16. van Marum, R.J., Current
and future therapy in Alzheimer's disease. Fundam Clin Pharmacol,
2008. 22(3): p. 265-74.
17. Schwab, C. and P.L. McGeer, Inflammatory aspects of Alzheimer
disease and other neurodegenerative disorders. J Alzheimers
Dis, 2008. 13(4): p. 359-69.
18. Maczurek, A., K. Shanmugam, and G. Munch, Inflammation
and the redox-sensitive AGE-RAGE pathway as a therapeutic target
in Alzheimer's disease. Ann N Y Acad Sci, 2008. 1126:
p. 147-51.
19. Berbaum, K., K. Shanmugam, G. Stuchbury, F. Wiede, H. Korner,
and G. Munch, Induction of novel cytokines and chemokines by
advanced glycation endproducts determined with a cytometric bead
array. Cytokine, 2008. 41(3): p. 198-203.
Hardcover/
Bound Texts:
1. Neuroinflammation in Neuronal Death and Repair, Volume 82 (International
Review of Neurobiology.) G. Bagetta, editor (Hardcover - Jul 16,
2007) Amsterdam ; Boston : Elsevier Academic Press ©2007.
ISBN: 9780123739896 0123739896.
2. Interactions Between Neurons and Glia in Aging and Disease
by Joao Malva, Ana Cristina Rego, Rodrigo Cunha, and Catarina
Oliveira (Eds.) (Hardcover - Aug 22, 2007). 2007, Approx. 535
p., Hardcover ISBN: 978-0-387-70829-4 New York ; London : Springer,
2007.
3. Cytokines in the Genesis and Treatment of Cancer (Cancer Drug
Discovery and Development) by Michael A. Caligiuri and Michael
T. Lotze (Hardcover - April 20, 2007) Totowa, N.J. : Humana Press
©2007. ISBN: 9780896038202 0896038203 9781597454551 1597454559.
4. Chapter 10: Anti-TNF-alpha antibody and cancer cachexia, The
ASCRS Textbook of Colon and Rectal Surgery by J.M. Church, J.
Garcia-Aguilar, P.L. Roberts, and T.J. Saclarides; New York :
Springer ©2007. ISBN: 9780387248462 0387248463.
5. Spinal Reconstruction: Clinical Examples of Applied Basic Science,
Biomechanics and Engineering by Kai-Uwe Lewandrowski, Michael
J. Yaszemski, Iain Kalfas, and Paul Park (Hardcover - Feb 12,
2007) New York : Informa Healthcare ©2007. ISBN: 9780849398155
0849398150.
6. Olesen J, Jensen T. From Basic Pain Mechanisms to Headache.
Oxford University Press 2007.
7. Neuroimmunology: The Immune System and Alzheimers, in the 2007
Progress Report on Brain Research, Dana Alliance for Brain Initiatives,
Dana Press, New York ©2007.