Rapid improvement in pain and neurologic dysfunction in severe chronic sciatica is carefully documented in the comfort of the INR office setting. The rapid and gentle process does not require anesthesia. The patented off-label method of treatment utilized was invented at the INR where it has been used for more than a decade. Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. The method utilized for this indication is off-label.