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Scientific Citations

Browse scientific citations to Dr. Edward Tobinick’s published work and explore the continued impact of his contributions in the field of neuroinflammation and neurological recovery.

Scientific research builds upon previously published discoveries, with researchers citing earlier studies as an essential part of the scientific process. Dr. Edward Tobinick, founder of the Institute of Neurological Recovery, has authored research that has been cited thousands of times in the scientific literature. A selection of these citations is provided below. Dr. Tobinick’s scientific findings have been published in multiple, peer-reviewed medical journals, including BMC Neurology, Clinical Drug Investigation, Clinical Therapeutics, CNS Drugs, Current Alzheimer Research, Current Medical Research and Opinion, Drug Discovery Today, Expert Review of Neurotherapeutics; and in medical and scientific textbooks, including Mechanisms of Neuroinflammation (InTech, 2017); and New Therapeutics for Traumatic Brain Injury (Academic Press, 2017).

Citations to Publications of Edward Tobinick, M.D.

In 2017:

  1. Allison, D.J., A.R. Josse, D.A. Gabriel, P. Klentrou, and D.S. Ditor, Targeting inflammation to influence cognitive function following spinal cord injury: a randomized clinical trial. Spinal Cord, 2017. 55(1): p. 26-32.
  2. Bagyinszky, E., V.V. Giau, K. Shim, K. Suk, S.S.A. An, and S. Kim, Role of inflammatory molecules in the Alzheimer’s disease progression and diagnosis. J Neurol Sci, 2017. 376: p. 242-254.
  3. Barami, K., Letter: Low-Pressure Hydrocephalus in Children: A Case Series and Review of the Literature. Neurosurgery, 2017. 81(5): p. E66.
  4. Chang, R., J. Knox, J. Chang, A. Derbedrossian, V. Vasilevko, D. Cribbs, R.J. Boado, W.M. Pardridge, and R.K. Sumbria, Blood-Brain Barrier Penetrating Biologic TNF-alpha Inhibitor for Alzheimer’s Disease. Mol Pharm, 2017. 14(7): p. 2340-2349.
  5. Chang, R., K.L. Yee, and R.K. Sumbria, Tumor necrosis factor alpha Inhibition for Alzheimer’s Disease. J Cent Nerv Syst Dis, 2017. 9: p. 1179573517709278.
  6. Clark, I.A., An unsound AAN Practice Advisory on poststroke PSE. Expert Rev Neurother, 2017. 17(3): p. 215-217.
  7. Clark, I.A. and B. Vissel, The meteorology of cytokine storms, and the clinical usefulness of this knowledge. Semin Immunopathol, 2017. 39(5): p. 505-516.
  8. Dasli, S., M. Topdag, A. Mutlu, A. Kara, and M. Ozturk, Prophylactic etanrcept treatment in cisplatin ototoxicity. Eur Arch Otorhinolaryngol, 2017. 274(10): p. 3577-3583.
  9. Deardorff, W.J. and G.T. Grossberg, Targeting neuroinflammation in Alzheimer’s disease: evidence for NSAIDs and novel therapeutics. Expert Rev Neurother, 2017. 17(1): p. 17-32.
  10. Decourt, B., D.K. Lahiri, and M.N. Sabbagh, Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease. Curr Alzheimer Res, 2017. 14(4): p. 412-425.
  11. Donat, C.K., G. Scott, S.M. Gentleman, and M. Sastre, Microglial Activation in Traumatic Brain Injury. Front Aging Neurosci, 2017. 9: p. 208.
  12. Frega, G., I. Garajova, A. Palloni, M.A. Barbera, M. Trossello Pastore, L. Faccioli, L. Spinardi, S. De Lorenzo, M. Cubelli, M.A. Pantaleo, G. Biasco, and G. Brandi, Brain Metastases from Biliary Tract Cancer: A Monocentric Retrospective Analysis of 450 Patients. Oncology, 2017.
  13. Hollander, M.C., L.L. Latour, D. Yang, H. Ishii, Z. Xiao, Y. Min, A. Ray-Choudhury, J. Munasinghe, A.S. Merchant, P.C. Lin, J. Hallenbeck, M. Boehm, and L. Yang, Attenuation of Myeloid Specific TGFbeta Signaling Induces Inflammatory Cerebrovascular Disease and Stroke. Circ Res, 2017.
  14. Leyns, C.E.G. and D.M. Holtzman, Glial contributions to neurodegeneration in tauopathies. Mol Neurodegener, 2017. 12(1): p. 50.
  15. Li, B., Y. Gao, W. Zhang, and J.R. Xu, Regulation and effects of neurotrophic factors after neural stem cell transplantation in a transgenic mouse model of Alzheimer disease. J Neurosci Res, 2017.
  16. Menzel, L., L. Kleber, C. Friedrich, R. Hummel, L. Dangel, J. Winter, K. Schmitz, I. Tegeder, and M.K. Schafer, Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury. Glia, 2017. 65(2): p. 278-292.
  17. Misiak, B., J.A. Beszlej, K. Kotowicz, M. Szewczuk-Boguslawska, J. Samochowiec, J. Kucharska-Mazur, and D. Frydecka, Cytokine alterations and cognitive impairment in major depressive disorder: From putative mechanisms to novel treatment targets. Prog Neuropsychopharmacol Biol Psychiatry, 2018. 80(Pt C): p. 177-188.
  18. Mohlenhoff, B.S., A. O’Donovan, M.W. Weiner, and T.C. Neylan, Dementia Risk in Posttraumatic Stress Disorder: the Relevance of Sleep-Related Abnormalities in Brain Structure, Amyloid, and Inflammation. Curr Psychiatry Rep, 2017. 19(11): p. 89.
  19. Paouri, E., O. Tzara, G.I. Kartalou, S. Zenelak, and S. Georgopoulos, Peripheral Tumor Necrosis Factor-Alpha (TNF-alpha) Modulates Amyloid Pathology by Regulating Blood-Derived Immune Cells and Glial Response in the Brain of AD/TNF Transgenic Mice. J Neurosci, 2017. 37(20): p. 5155-5171.
  20. Paouri, E., O. Tzara, S. Zenelak, and S. Georgopoulos, Genetic Deletion of Tumor Necrosis Factor-alpha Attenuates Amyloid-beta Production and Decreases Amyloid Plaque Formation and Glial Response in the 5XFAD Model of Alzheimer’s Disease. J Alzheimers Dis, 2017. 60(1): p. 165-181.
  21. Piirainen, S., A. Youssef, C. Song, A.V. Kalueff, G.E. Landreth, T. Malm, and L. Tian, Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer’s disease: the emerging role for microglia? Neurosci Biobehav Rev, 2017. 77: p. 148-164.
  22. Rodriguez-Grande, B., A. Ichkova, S. Lemarchant, and J. Badaut, Early to Long-Term Alterations of CNS Barriers After Traumatic Brain Injury: Considerations for Drug Development. AAPS J, 2017. 19(6): p. 1615-1625.
  23. Shapira, R., B. Solomon, S. Efrati, D. Frenkel, and U. Ashery, Hyperbaric oxygen therapy ameliorates pathophysiology of 3xTg-AD mouse model by attenuating neuroinflammation. Neurobiol Aging, 2017. 62: p. 105-119.
  24. Volgyi, K., K. Haden, V. Kis, P. Gulyassy, K. Badics, B.A. Gyorffy, A. Simor, Z. Szabo, T. Janaky, L. Drahos, A. Dobolyi, B. Penke, G. Juhasz, and K.A. Kekesi, Mitochondrial Proteome Changes Correlating with beta-Amyloid Accumulation. Mol Neurobiol, 2017. 54(3): p. 2060-2078.
  25. Xu, H., Z. Wang, J. Li, H. Wu, Y. Peng, L. Fan, J. Chen, C. Gu, F. Yan, L. Wang, and G. Chen, The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention. Neural Plast, 2017. 2017: p. 5405104.
  26. Yang, Y., J. Zhang, Q. Gao, J. Bo, and Z. Ma, Etanercept attenuates thermal and mechanical hyperalgesia induced by bone cancer. Experimental and Therapeutic Medicine, 2017. 13(5): p. 2565–2569.

In 2014:

  1. Bae WC, Masuda K. Chapter 25: Enhancing Disc Repair by Growth Factors and Other Modalities. In: Shapiro IM, Risbud MV, editors. The Intervertebral Disc. Wien: Springer-Verlag; 2014.
  2. Bastos LF, Coelho MM. Drug repositioning: playing dirty to kill pain. CNS Drugs. 2014;28(1):45-61.
  3. Clark IA, Vissel B. Inflammation-sleep interface in brain disease: TNF, insulin, orexin. J Neuroinflammation. 2014;11(1):51.
  4. Faingold CL. Chapter 7: Network Control Mechanisms: Cellular Inputs, Neuroactive Substances, and Synaptic Changes. In: Faingold CL, Blumenfeld H, editors. Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics: Elsevier; 2014.
  5. Ferreira ST, Clarke JR, Bomfim TR, De Felice FG. Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer’s disease. Alzheimers Dement. 2014;10(1S):S76-S83.
  6. Gisondi P, Sala F, Alessandrini F, Avesani V, Zoccatelli G, Beltramello A, et al. Mild cognitive impairment in patients with moderate to severe chronic plaque psoriasis. Dermatology. 2014;228(1):78-85.
  7. Griessenauer CJ, Raborn J, Foreman P, Shoja MM, Loukas M, Tubbs RS. Venous Drainage of the Spine and Spinal Cord: A Comprehensive Review of its History, Embryology, Anatomy, Physiology, and Pathology. Clinical Anatomy. 2014;epub.
  8. Najem D, Bamji-Mirza M, Chang N, Liu QY, Zhang W. Insulin resistance, neuroinflammation, and Alzheimer’s disease. Rev Neurosci. 2014.
  9. Ohtori S, Inoue G, Miyagi M, Takahashi K. Pathomechanisms of discogenic low back pain in humans and animal models. Spine J. 2014.
  10. Sem DS. Repurposing – Finding New Uses for Old (and Patented) Drugs: Bridging the “Valley of Death,” to Translate Academic Research Into New Medicines. Marquette Intellectual Property Law Review. 2014;18(1):139-66.
  11. Siniscalchi A, Gallelli L, Malferrari G, Pirritano D, Serra R, Santangelo E, et al. Cerebral stroke injury: the role of cytokines and brain inflammation. J Basic Clin Physiol Pharmacol. 2014.
  12. Starke RM, Raper DM, Ding D, Chalouhi N, Owens GK, Hasan DM, et al. Tumor Necrosis Factor-alpha Modulates Cerebral Aneurysm Formation and Rupture. Transl Stroke Res. 2014;5(2):269-77.
  13. Sun Q, Hampel H, Blennow K, Lista S, Levey A, Tang B, et al. Increased Plasma TACE Activity in Subjects with Mild Cognitive Impairment and Patients with Alzheimer’s Disease. Journal of Alzheimer’s disease : JAD. 2014.
  14. Trager U, Andre R, Lahiri N, Magnusson-Lind A, Weiss A, Grueninger S, et al. HTT-lowering reverses Huntington’s disease immune dysfunction caused by NFkappaB pathway dysregulation. Brain. 2014;137(Pt 3):819-33.
  15. Tronel C, Page G, Bodard S, Chalon S, Antier D. The specific PKR inhibitor C16 prevents apoptosis and IL-1beta production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014;64:73-83.
  16. Winkelstein BA, Allen KD, Setton LA. Chapter 19: Intervertebral Disc Herniation: Pathophysiology and Emerging Therapies. In: Shapiro IM, Risbud MV, editors. The Intervertebral Disc. Wien, Austria: Springer-Verlag; 2014.

In 2012:

  1. Belarbi K, et al. TNF-alpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J Neuroinflammation. 2012;9:23.
  2. Bomfim TR, et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease-associated Abeta oligomers. J Clin Invest. 2012;122(4):1339–53.
  3. Butchart J, Holmes C. Systemic and central immunity in Alzheimer’s disease: therapeutic implications. CNS Neurosci Ther. 2012;18(1):64–76.
  4. Cereda C, et al. The Role of TNF-alpha in ALS: New Hypotheses for Future Therapeutic Approaches. In: Amyotrophic Lateral Sclerosis. InTech; 2012. p. 413–436.
  5. Clark IA, et al. Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer’s disease links numerous treatment rationales. Pharmacol Rev. 2012;64(4):1004–26.
  6. Dhawan G, Combs CK. Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer’s disease. J Neuroinflammation. 2012;9:117.
  7. Drent M, Lower EE, De Vries J. Sarcoidosis-associated fatigue. Eur Respir J. 2012;40(1):255–63.
  8. Ferraccioli G, et al. Rheumatoid Arthritis and Alzheimer Disease: Possible Cellular and Molecular Links. Gerontology and Geriatric. 2012;1(1).
  9. Gabbita SP, et al. Early intervention with a small molecule inhibitor for tumor necrosis factor-alpha prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease. J Neuroinflammation. 2012;9:99.
  10. Gruber HE, et al. Genome-wide analysis of pain-, nerve- and neurotrophin-related gene expression in the degenerating human annulus. Mol Pain. 2012;8:63.
  11. Hojlund J, et al. Effect of head rotation on cerebral blood velocity in the prone position. Anesthesiol Res Pract. 2012;2012:647258.
  12. Ingles-Esteve J, et al. Inhibition of specific NF-kappaB activity contributes to tumor suppressor function. PLoS One. 2012;7(5):e38347.
  13. Jiang T, Yu JT, Tan L. Novel disease-modifying therapies for Alzheimer’s disease. J Alzheimers Dis. 2012;31(3):475–92.
  14. Krishnadas R, Cavanagh J. Depression: an inflammatory illness? J Neurol Neurosurg Psychiatry. 2012;83(5):495–502.
  15. Landoni VI, et al. Shiga toxin 1 induces TNF-alpha release in astrocytes altering brain endothelium integrity. PLoS Pathog. 2012;8(3):e1002632.
  16. Lauterbach EC. Psychotropic drug effects on gene transcriptomics relevant to Alzheimer disease. Alzheimer Dis Assoc Disord. 2012;26(1):1–7.
  17. Lima A, Antunes F. Intervention of Physical Medicine and Rehabilitation in Failed Back Surgery Syndrome. J Reg Anaesth Pain Manag. 2012;68:29–30.
  18. Maccioni RB, et al. In Search of Therapeutic Solutions for Alzheimer’s Disease. In: When Things Go Wrong—Diseases and Disorders of the Human Brain. InTech; 2012.
  19. Matias-Guiu JA, Garcia-Ramos R. Primary progressive aphasia: from syndrome to disease. Neurologia. 2012.
  20. Montgomery SL, Bowers WJ. Tumor Necrosis Factor-alpha and CNS homeostatic and degenerative processes. J Neuroimmune Pharmacol. 2012;7(1):42–59.
  21. Ooi L, et al. New drugs under development for Alzheimer’s disease. In: Advances in Alzheimer’s Disease Management. 2012. p. 58–67.
  22. Ramesh V, et al. Disrupted sleep induces cognitive dysfunction via TNF-alpha pathway. J Neuroinflammation. 2012;9.
  23. Santello M, Volterra A. TNF-alpha in synaptic function: switching gears. Trends Neurosci. 2012;35(10):638–47.
  24. Singh PL, et al. Current therapeutic strategies for inflammation following spinal cord injury. Neural Regen Res. 2012;7(23):1812–21.
  25. Steele ML, Robinson SR. Reactive astrocytes give neurons less support: implications for Alzheimer’s disease. Neurobiol Aging. 2012;33(2):e423–13.
  26. Stringer MD, et al. The vertebral venous plexuses: muscular internal veins and valved external veins. Clin Anat. 2012;25(5):609–18.
  27. Tweedie D, et al. TNF-alpha synthesis inhibitor attenuates inflammation and Alzheimer pathology. J Neuroinflammation. 2012;9:106.
  28. Wilcock DM. Neuroinflammation in the aging Down syndrome brain; lessons from Alzheimer’s disease. Curr Gerontol Geriatr Res. 2012;2012:170276.
  29. Woodward MC. Drug treatments in development for Alzheimer’s disease. J Pharm Pract Res. 2012;42(1):58–65.
  30. Yoshiyama Y, Lee VM, Trojanowski JQ. Therapeutic strategies for tau mediated neurodegeneration. J Neurol Neurosurg Psychiatry. 2012.

In 2010 and 2011:

    • Aderinwale, O.G., H.W. Ernst, and S.A. Mousa, Current therapies and new strategies for the management of Alzheimer’s disease. Am J Alzheimers Dis Other Demen, 2010. 25: (5): p. 414-24.
    • Bassi, E. and C. De Filippi, Beneficial neurological effects observed in a patient with psoriasis treated with etanrcept. Am J Clin Dermatol, 2010. 11 Suppl 1: p. 44-5.
    • Boettger, M.K., et al., Spinal tumor necrosis factor alpha neutralization reduces peripheral inflammation and hyperalgesia and suppresses autonomic responses in experimental arthritis: a role for spinal tumor necrosis factor alpha during induction and maintenance of peripheral inflammation. Arthritis Rheum, 2010. 62(5): p. 1308-18.
    • Buchhave, P., et al., Soluble TNF receptors are associated with Abeta metabolism and conversion to dementia in subjects with mild cognitive impairment. Neurobiol Aging, 2010. 31(11): p. 1877-84.
    • Candore, G., et al., Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications. Rejuvenation Res, 2010. 13(2-3): p. 301-13.
    • Chavant, F., et al., Imipramine, in part through tumor necrosis factor alpha inhibition, prevents cognitive decline and beta-amyloid accumulation in a mouse model of Alzheimer’s disease. J Pharmacol Exp Ther, 2010. 332(2): p. 505-14.
    • Chez, M.G. and N. Guido-Estrada, Immune therapy in autism: historical experience and future directions with immunomodulatory therapy. Neurotherapeutics, 2010. 7(3): p. 293-301.
    • Clark, I.A., L.M. Alleva, and B. Vissel, The roles of TNF in brain dysfunction and disease. Pharmacol Ther, 2010.128(3): p. 519-48.
    • Colton, C.A. and D.M. Wilcock, Assessing activation states in microglia. CNS Neurol Disord Drug Targets, 2010.9(2): p. 174-91.
    • Dumont, T.M., D.W. Stockwell, and M.A. Horgan, Venous air embolism: an unusual complication of atlantoaxial arthrodesis: case report. Spine (Phila Pa 1976), 2010. 35(22): p. E1238-40.
    • Duro, D., et al., Validation studies of the Portuguese experimental version of the Montreal Cognitive Assessment (MoCA): confirmatory factor analysis. J Neurol, 2010. 257(5): p. 728-34.
    • Elfferich, M.D., et al., Everyday cognitive failure in sarcoidosis: the prevalence and the effect of anti-TNF-alpha treatment. Respiration, 2010. 80(3): p. 212-9.
    • Esposito, E. and S. Cuzzocrea, Anti-TNF therapy in the injured spinal cord. Trends Pharmacol Sci. 2011 Feb;32(2):107-15.
    • Frankola KA, Greig NH, Luo W, Tweedie D. Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases. CNS Neurol Disord Drug Targets. 2011 Feb 2. [Epub ahead of print] PMID: 21288189.
    • Furst, D.E., et al., Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2009. Ann Rheum Dis, 2010. 69 Suppl 1: p. i2-29.
    • Galimberti D, Scarpini E. Alzheimer’s Disease: From Pathogenesis to Disease-Modifying Approaches. CNS & Neurological Disorders – Drug Targets March 2011. 10(2):163-174.
    • Geis, C., et al., Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain. Neuroscience, 2010. 169(1): p. 463-74.
    • Gu, X., et al., Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-alpha expression in a mouse model. Mol Pain, 2010. 6: p. 64.
    • He, M.X., et al., Association between interleukin-6 gene promoter -572C/G polymorphism and the risk of sporadic Alzheimer’s disease. Neurol Sci, 2010. 31(2): p. 165-8.
    • Huang, H., et al., TNF{alpha} is required for late BRB breakdown in diabetic retinopathy and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. Invest Ophthalmol Vis Sci, 2011 Jan 6.
    • Landoni, V.I., et al., Shiga toxin 1-induced inflammatory response in lipopolysaccharide-sensitized astrocytes is mediated by endogenous tumor necrosis factor alpha. Infect Immun, 2010. 78(3): p. 1193-201.
    • Lanni, C., et al., The expanding universe of neurotrophic factors: therapeutic potential in aging and age-associated disorders. Curr Pharm Des, 2010. 16(6): p. 698-717.
    • Lauterbach, E., Psychotropic Drug Effects on Gene Transcriptomics Relevant to Alzheimer Disease. Alzheimer disease and associated disorders, 2011. in press, DOI: 10.1097/WAD.0b013e318214b7d0.
    • Liu, Z.P., et al., Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer’s disease brains. BMC Syst Biol, 2010. 4 Suppl 2: p. S11.
    • McIntyre, R.S., et al., Brain volume abnormalities and neurocognitive deficits in diabetes mellitus: points of pathophysiological commonality with mood disorders? Adv Ther, 2010. 27(2): p. 63-80.
    • McNaull, B.B., et al., Inflammation and anti-inflammatory strategies for Alzheimer’s disease–a mini-review. Gerontology, 2010. 56(1): p. 3-14.
    • Menza M, Dobkin RD, Marin H, Mark MH, Gara M, Bienfait K, Dicke A, Kusnekov A. The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson’s disease. Psychosomatics. 2010 Nov;51(6):474-9.
    • Merino, A., et al., Drug profiling: knowing where it hits. Drug Discov Today, 2010. 15(17-18): p. 749-56.
    • Money, T.T., et al., Treating schizophrenia: novel targets for the cholinergic system. CNS Neurol Disord Drug Targets, 2010. 9(2): p. 241-56.
    • Munoz, L. and A.J. Ammit, Targeting p38 MAPK pathway for the treatment of Alzheimer’s disease. Neuropharmacology, 2010. 58(3): p. 561-8.
    • Nicolae, C. and B.R. Olsen, Unexpected matrix diseases and novel therapeutic strategies. Cell Tissue Res, 2010.339(1): p. 155-65.
    • Oldreive, C.E. and G.H. Doherty, Effects of tumour necrosis factor-alpha on developing cerebellar granule and Purkinje neurons in vitro. J Mol Neurosci, 2010. 42(1): p. 44-52.
    • Pan, S.Y., et al., New perspectives on innovative drug discovery: an overview. J Pharm Pharm Sci, 2010. 13(3): p. 450-71.
    • Potter, P.E., Investigational medications for treatment of patients with Alzheimer disease. J Am Osteopath Assoc, 2010.110(9 Suppl 8): p. S27-36.
    • Ramanan, S., et al., Role of PPARs in Radiation-Induced Brain Injury. PPAR Res, 2010. 2010: p. 234975.
    • Seigers, R. and J.E. Fardell, Neurobiological basis of chemotherapy-induced cognitive impairment: a review of rodent research. Neurosci Biobehav Rev, 2011. 35(3): p. 729-41.
    • Shi JQ, Shen W, Chen J, Wang BR, Zhong LL, Zhu YW, Zhu HQ, Zhang QQ, Zhang YD, Xu J. Anti-TNF-alpha reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains. Brain Res. 2011 Jan 12;1368:239-47.
    • Simen AA, Bordner KA, Martin MP, et. al., Cognitive dysfunction with aging and the role of inflammation. Therapeutic Advances in Chronic Disease, 2011. Published online before print February 15, 2011, doi:10.1177/2040622311399145.
    • Sinclair, S.M., et al., Attenuation of Inflammatory Events in Human Intervertebral Disc Cells with a Tumor Necrosis Factor Antagonist. Spine (Phila Pa 1976), 2011 Jan 6.
    • Tamayo AC, Guajardo-Rosas J. Cervical epidural injections for radicular pain. Techniques in Regional Anesthesia and Pain Management. Volume 14, Issue 3, July 2010, Pages 106-112.
    • Vinukonda, G., et al., Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition. Brain, 2010. 133(Pt 8): p. 2264-80.
    • Wang, M.J., et al., Glycogen synthase kinase-3beta inactivation inhibits tumor necrosis factor-alpha production in microglia by modulating nuclear factor kappaB and MLK3/JNK signaling cascades. J Neuroinflammation, 2010. 7: p. 99.

Relevant Scientific Publications

Relevant Scientific References: 2012-2013[1-41] 2003-2011[42-118]
*Asterisk indicates that the designated Scientific Reference has cited one of more of the scientific publications of Edward Tobinick
  1. Acton QA: Chapter 15: Neurotherapeutics. In Issues in Neurological Surgery and Specialties: 2011 Edition. Edited by Acton QA. Atlanta, Georgia: ScholarlyEditions; 2012: 1601-1631
  2. Belarbi K, Jopson T, Tweedie D, Arellano C, Luo W, Greig NH, Rosi S: TNF-alpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J Neuroinflammation 2012, 9:23.
  3. Chou SH, Feske SK, Atherton J, Konigsberg RG, De Jager PL, Du R, Ogilvy CS, Lo EH, Ning M: Early Elevation of Serum Tumor Necrosis Factor-alpha Is Associated With Poor Outcome in Subarachnoid Hemorrhage. J Investig Med 2012.
  4. Clark I: New hope for survivors of stroke and traumatic brain injury. CNS Drugs 2012, 26:1071-1072.
  5. Clark I, Atwood C, Bowen R, Paz-Filho G, Vissel B: Tumor Necrosis Factor-Induced Cerebral Insulin Resistance in Alzheimer’s Disease Links Numerous Treatment Rationales. Pharmacological Reviews 2012, 64:1004-1026.
  6. Delrieu J, Piau A, Vellas B: Chapter 78: Drug Development and Alzheimer’s Disease. In Pathy’s Principles and Practice of Geriatric Medicine, Fifth Edition. Edited by Sinclair AJ, Morley JE, Vellas B. West Sussex, UK: Wiley-Blackwell; 2012
  7. Elcioglu H, Kabasakal L, Alan S, Salva E, Tufan F, Karan M: Thalidomide attenuates learning and memory deficits induced by intracerebroventricular administration of streptozotocin in rats. Biotech Histochem 2012.
  8. Ferraccioli G, Gremese E, Carbonella A, Alivernini S: Rheumatoid Arthritis and Alzheimer Disease: Possible Cellular and Molecular Links. J Gerontol Geriatric Res 2012, 1:e104.
  9. Gabbita SP, Srivastava MK, Eslami P, Johnson MF, Kobritz NK, Tweedie D, Greig NH, Zemlan FP, Sharma SP, Harris-White ME: Early intervention with a small molecule inhibitor for tumor necrosis factor-alpha prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease. J Neuroinflammation 2012, 9:99.
  10. Gruber HE, Hoelscher GL, Ingram JA, Hanley EN, Jr.: Genome-wide analysis of pain-, nerve- and neurotrophin-related gene expression in the degenerating human annulus. Mol Pain 2012, 8:63.
  11. Jiang T, Yu JT, Tan L: Novel disease-modifying therapies for Alzheimer’s disease. J Alzheimers Dis 2012, 31:475-492.
  12. Lauterbach EC: Psychotropic drug effects on gene transcriptomics relevant to Alzheimer disease. Alzheimer Dis Assoc Disord 2012, 26:1-7.
  13. Maccioni RB, Farias G, Rojo LE, Jimenez JM: In Search of Therapeutic Solutions for Alzheimer’s Disease. In When Things Go Wrong – Diseases and Disorders of the Human Brain. Edited by Mantamadiotis T. Rijeka, Croatia: InTech; 2012: 125-150
  14. Matias-Guiu JA, Garcia-Ramos R: Primary progressive aphasia: from syndrome to disease. Neurologia 2012.
  15. Maudsley S, Chadwick W: Progressive and unconventional pharmacotherapeutic approaches to Alzheimer’s disease therapy. Curr Alzheimer Res 2012, 9:1-4.
  16. Ohtori S, Miyagi M, Eguchi Y, Inoue G, Orita S, Ochiai N, Kishida S, Kuniyoshi K, Nakamura J, Aoki Y, et al: Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanrcept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study. Spine (Phila Pa 1976) 2012, 37:439-444.
  17. Ooi L, al. e: New Drugs Under Development for Alzheimer’s Disease. In Advances in Alzheimer’s Disease Management. Edited by Gauthier S, Rosa-Neto P; 2012: 58-67
  18. Raffaghello L, Bianchi G, Pistoia V: Immunosuppressive treatments in acute myocardial infarction and stroke. Curr Pharm Biotechnol 2012, 13:59-67.
  19. Ramesh V, Nair D, Zhang SX, Hakim F, Kaushal N, Kayali F, Wang Y, Li RC, Carreras A, Gozal D: Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-alpha pathway. J Neuroinflammation 2012, 9:91.
  20. Roh M, Zhang Y, Murakami Y, Thanos A, Lee SC, Vavvas DG, Benowitz LI, Miller JW: Etanrcept, a widely used inhibitor of tumor necrosis factor-alpha (TNF-alpha), prevents retinal ganglion cell loss in a rat model of glaucoma. PLoS One 2012, 7:e40065.
  21. Santello M, Volterra A: TNFalpha in synaptic function: switching gears. Trends Neurosci 2012, 35:638-647.
  22. Smith C, Gentleman SM, Leclercq PD, Murray LS, Griffin WS, Graham DI, Nicoll JA: The neuroinflammatory response in humans after traumatic brain injury. Neuropathol Appl Neurobiol 2012.
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  43. Tobinick EL, Britschgi-Davoodifar S: Perispinal TNF-alpha inhibition for discogenic pain. Swiss Med Wkly 2003, 133:170-177.
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  49. Tobinick E, Gross H, Weinberger A, Cohen H: TNF-alpha modulation for treatment of Alzheimer’s disease: a 6-month pilot study. MedGenMed 2006, 8:25.
  50. Tobinick E, Vega CP: The cerebrospinal venous system: anatomy, physiology, and clinical implications. MedGenMed 2006, 8:53.
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  63. Tobinick EL, Gross H: Rapid cognitive improvement in Alzheimer’s disease following PSE administration. J Neuroinflammation 2008, 5:2.
  64. Tobinick EL, Gross H: Rapid improvement in verbal fluency and aphasia following PSE in Alzheimer’s disease. BMC Neurol 2008, 8:27.
  65. Youn DH, Wang H, Jeong SJ: Exogenous tumor necrosis factor-alpha rapidly alters synaptic and sensory transmission in the adult rat spinal cord dorsal horn. J Neurosci Res 2008, 86:2867-2875.
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  76. Tobinick E: Tumour necrosis factor modulation for treatment of Alzheimer’s disease: rationale and current evidence. CNS Drugs 2009, 23:713-725.
  77. Tobinick EL, Chen K, Chen X: Rapid intracerebroventricular delivery of Cu-DOTA-etanrcept after peripheral administration demonstrated by PET imaging. BMC Res Notes 2009, 2:28.
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  84. Chio CC, Lin JW, Chang MW, Wang CC, Yang CZ, Chang CP: Therapeutic evaluation of etanrcept in a model of traumatic brain injury. J Neurochem 2010, 115:921-929.
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  86. Colton C, Wilcock DM: Assessing activation states in microglia. CNS Neurol Disord Drug Targets 2010, 9:174-191.
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  93. Park KM, Bowers WJ: Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal 2010, 22:977-983.
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  95. Baratz R, Tweedie D, Rubovitch V, Luo W, Yoon JS, Hoffer BJ, Greig NH, Pick CG: Tumor necrosis factor-alpha synthesis inhibitor, 3,6‚-thiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice. Journal of neurochemistry 2011.
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  114. Shen CH, Tsai RY, Shih MS, Lin SL, Tai YH, Chien CC, Wong CS: Etanrcept restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in morphine-tolerant rats. Anesth Analg 2011, 112:454-459.
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  116. Simen AA, Bordner KA, Martin MP, Moy LA, Barry LC: Cognitive dysfunction with aging and the role of inflammation. Therapeutic Advances in Chronic Disease 2011, 2:175-195.
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