Pain after stroke represents an enormous unmet medical need for those who do not adequately respond to conventional treatment. Chronic central post-stroke pain affects countless stroke survivors around the world. This video depicts the presence of chronic central post-stroke pain prior to treatment at the Institute of Neurological Recovery in Boca Raton. Included is a demonstration of allodynia, i.e. pain or discomfort produced by a sensory stimulus, in this case cold, that normally would not provoke discomfort. In many individuals with central post-stroke pain sensory stimuli, such as light touch, that would normally not be noxious, produce extreme discomfort. Some individuals are unable to tolerate normal touch or even showering because of this post-stroke pain condition. This video depicts the rapid response to a single treatment dose administered on May 7, 2015 at the INR PLLC.