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Perispinal Etanercept (PSE) Treatment

Learn more about the Institute’s unique, patented, anti-inflammatory
treatment.

Scientific research over the past several decades has expanded our understanding of neuroinflammation – the inflammatory processes that occur within the brain and nervous system following injury or disease. While inflammation is a normal part of the body’s healing response, persistent or dysregulated neuroinflammation has been implicated in a variety of chronic neurological conditions, including stroke, traumatic brain injury, Alzheimer’s disease, and other disorders.

One of the key signaling molecules involved in this process is tumor necrosis factor (TNF). TNF is an immune signaling protein that plays an important role in normal brain function, including communication between nerve cells. However, excessive TNF activity has been associated with chronic neuroinflammation, altered synaptic function, and persistent neurological dysfunction following brain injury.

Etanercept is a medication that inhibits TNF and has been widely used for many years to treat autoimmune inflammatory diseases such as rheumatoid arthritis. Perispinal etanercept (PSE) utilizes a patented method of administering etanercept that was developed by Edward Tobinick, MD, with the goal of delivering the medication using a specialized perispinal technique for the evaluation and treatment of select neurological conditions.

Dr. Tobinick has published extensively on the scientific rationale for PSE treatment, including the role of TNF in neuroinflammation and neurological dysfunction. This work has contributed to ongoing scientific discussion and research investigating the relationship between neuroinflammation and chronic neurological disease.

To learn more, explore our collection of peer-reviewed publications and scientific resources discussing the role of neuroinflammation, TNF, and PSE treatment.
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  • Common Questions

Frequently Asked Questions

Perispinal etanercept is a method of targeting detrimental neuroinflammation using etanercept, a special anti-inflammatory drug, delivered utilizing a novel, non-invasive injection method.

Perispinal etanercept is NOT experimental. Perispinal etanercept has been used to treat more than 5,000 chronic stroke patients since 2010 at the Institute of Neurological Recovery.

Perispinal etanercept is NOT a spinal injection. The small needle utilized is much too short to reach the spinal canal or the epidural space.

No, it is not too late. Neuroinflammation can last for years, or even decades, after brain injury. Life-changing neurological improvements following perispinal etanercept treatment performed weeks, months, years, or even decades after stroke or brain injury are not uncommon.

Referrals are not required. The Institute of Neurological Recovery has received, and welcomes, referrals from neurologists, speech pathologists, physical therapists, occupational therapists, primary care physicians, online stroke groups, and, of course, patients and their family members.

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Receive detailed information regarding the Institute’s unique, patented, anti-inflammatory treatment. We currently treat and accept new patients from around the world, even years or decades after stroke or traumatic brain injury.

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