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INR 100 UCLA Medical Plaza, Suites 205-210 Los Angeles, California 90095 (310) 824-6199 Edward Tobinick MD, Medical Director

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Selected INR publications

Tobinick E
Perispinal etanercept produces rapid improvement in primary progressive aphasia: Identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanism.
Medscape J Med 2008; 10(6):135.

Tobinick EL, Gross H
Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease.
BMC Neurol 2008 Jul 21; 8(1):27.

Tobinick EL
Re: Inflammatory markers and the risk of Alzheimer disease: the Framingham Study.
Neurology 2008 Apr 1; 70(14):1222-3; author reply 1223.

Tobinick E
Perispinal etanercept for treatment of Alzheimer's disease.
Curr Alzheimer Res 2007 Dec; 4(5):550-2.

Tobinick EL
A critique of intradiscal administration for treatment of radiculopathy.
Anesthesiology 2008 Feb; 108(2):334; author reply 335.

Tobinick EL, Gross H
Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration.
J Neuroinflammation 2008 Jan 9; 5(1):2.

Tobinick E
Spinal Delivery of p38: TNF-alpha Inhibitors.
PLoS Med 2006 Nov; 3(11):e511.

Tobinick E, Gross H, Weinberger A, Cohen H.
TNF-alpha Modulation for Treatment of Alzheimer's Disease: A 6-Month Pilot Study.
MedGenMed 2006; 8(2):25.

Tobinick E
The Cerebrospinal Venous System: Anatomy, Physiology, and Clinical Implications.
MedGenMed 2006; 8(1):53.

Tobinick E, Davoodifar S
Efficacy of etanercept delivered by perispinal administration for chronic back and/or neck disc-related pain: a study of clinical observations in 143 patients.
Curr Med Res Opin 2004 Jul; 20(7):1075-85.

Tobinick E
TNF-alpha inhibition for potential therapeutic modulation of SARS coronavirus infection.
Curr Med Res Opin 2004 Jan; 20(1):39-40.

Tobinick EL
Targeted etanercept for treatment-refractory pain due to bone metastasis: two case reports.
Clin Ther 2003 Aug; 25(8):2279-88.

Tobinick EL
Targeted etanercept for discogenic neck pain: uncontrolled, open-label results in two adults.
Clin Ther 2003 Apr; 25(4):1211-8.

Tobinick EL, Britschgi-Davoodifar S
Perispinal TNF-alpha inhibition for discogenic pain.
Swiss Med Wkly 2003 Mar 22; 133(11-12):170-7.

Scientific Articles:
1. Griffin WS. Perispinal etanercept: Potential as an Alzheimer therapeutic. J Neuroinflammation. 2008 Jan 10;5(1):3. [download free full-text PDF].
2. Misra, Ambikanandan; Jogani, Viral; Jinturkar, Kaustubh; Vyas, Tushar. Recent Patents Review on Intranasal Administration for CNS Drug Delivery. Recent Patents on Drug Delivery & Formulation, Volume 2, Number 1, January 2008 , pp. 25-40(16).
3. Zanella, John M. MS; Burright, Eric N. PhD; Hildebrand, Keith DVM, PhD; Hobot, Chris BS; Cox, Mark BS; Christoferson, Laura BS; McKay, William F. MS. Effect of Etanercept, a Tumor Necrosis Factor-Alpha Inhibitor, on Neuropathic Pain in the Rat Chronic Constriction Injury Model. Spine 33(3):227-234, February 1, 2008.
4. Sonya Vasto, Giuseppina Candore, Giovanni Duro, Domenico Lio, Maria Paola Grimaldi, Calogero Caruso. Alzheimer's disease and genetics of inflammation: a pharmacogenomic vision. Pharmacogenomics December 2007, Vol. 8, No. 12, Pages 1735-1745.
5. Tweedie D, Sambamurti K, Greig NH. Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, US. TNF-alpha Inhibition as a Treatment Strategy for Neurodegenerative Disorders: New Drug Candidates and Targets. Curr Alzheimer Res. 2007 Sep;4(4):375-8.
6. Van Eldik, L. J. Thompson, W. L. Ranaivo, H. R. Behanna, H. A. Watterson, D. M. Glia Proinflammatory Cytokine Upregulation as a Therapeutic Target for Neurodegenerative Diseases: Function-Based and Target-Based Discovery Approaches, International Review of Neurobiology 2007, 82:278-297.
7. Uceyler N, Sommer C. Cytokine-induced Pain: Basic Science and Clinical Implications. Reviews in Analgesia 2007;9(2):87-103.
8. Tubbs RS, Hansasuta A, Loukas M, Louis RG, Jr., Shoja MM, Salter EG, et al. The basilar venous plexus. Clin Anat 2007.
9. Saxena AK, Kumar S. Management strategies for pain in breast carcinoma patients: current opinions and future perspectives. Pain Pract 2007;7(2):163-77.
10. Owlia MB, Salimzadeh A, Alishiri G, Haghighi A. Comparison of two doses of corticosteroid in epidural steroid injection for lumbar radicular pain. Singapore Med J 2007;48(3):241-5.
11. Munoz L, Ralay Ranaivo H, Roy SM, Hu W, Craft JM, McNamara LK, et al. A novel p38alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. J Neuroinflammation 2007;4(1):21.
12. Hu W, Ranaivo HR, Roy SM, Behanna HA, Wing LK, Munoz L, et al. Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits. Bioorg Med Chem Lett 2007;17(2):414-8.
13. Le Maitre CL, Hoyland JA, Freemont AJ. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther. 2007 Aug 9;9(4):R77.
14. Kenneth M. Kulmatycki1, Fakhreddin Jamali. Drug Disease Interactions: Role of Inflammatory Mediators in Pain and Variability in Analgesic Drug Response. J Pharm Pharm Sci, 10 (4): 554-566, 2007.
15. Schäfers, Maria; Sommer, Claudia. Anticytokine therapy in neuropathic pain management. Expert Review of Neurotherapeutics, Volume 7, Number 11, November 2007 , pp. 1613-1627(15).

16. van Marum, R.J., Current and future therapy in Alzheimer's disease. Fundam Clin Pharmacol, 2008. 22(3): p. 265-74.
17. Schwab, C. and P.L. McGeer, Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders. J Alzheimers Dis, 2008. 13(4): p. 359-69.
18. Maczurek, A., K. Shanmugam, and G. Munch, Inflammation and the redox-sensitive AGE-RAGE pathway as a therapeutic target in Alzheimer's disease. Ann N Y Acad Sci, 2008. 1126: p. 147-51.
19. Berbaum, K., K. Shanmugam, G. Stuchbury, F. Wiede, H. Korner, and G. Munch, Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array. Cytokine, 2008. 41(3): p. 198-203.

Hardcover/ Bound Texts:
1. Neuroinflammation in Neuronal Death and Repair, Volume 82 (International Review of Neurobiology.) G. Bagetta, editor (Hardcover - Jul 16, 2007) Amsterdam ; Boston : Elsevier Academic Press ©2007. ISBN: 9780123739896 0123739896.
2. Interactions Between Neurons and Glia in Aging and Disease by Joao Malva, Ana Cristina Rego, Rodrigo Cunha, and Catarina Oliveira (Eds.) (Hardcover - Aug 22, 2007). 2007, Approx. 535 p., Hardcover ISBN: 978-0-387-70829-4 New York ; London : Springer, 2007.
3. Cytokines in the Genesis and Treatment of Cancer (Cancer Drug Discovery and Development) by Michael A. Caligiuri and Michael T. Lotze (Hardcover - April 20, 2007) Totowa, N.J. : Humana Press ©2007. ISBN: 9780896038202 0896038203 9781597454551 1597454559.
4. Chapter 10: Anti-TNF-alpha antibody and cancer cachexia, The ASCRS Textbook of Colon and Rectal Surgery by J.M. Church, J. Garcia-Aguilar, P.L. Roberts, and T.J. Saclarides; New York : Springer ©2007. ISBN: 9780387248462 0387248463.
5. Spinal Reconstruction: Clinical Examples of Applied Basic Science, Biomechanics and Engineering by Kai-Uwe Lewandrowski, Michael J. Yaszemski, Iain Kalfas, and Paul Park (Hardcover - Feb 12, 2007) New York : Informa Healthcare ©2007. ISBN: 9780849398155 0849398150.
6. Olesen J, Jensen T. From Basic Pain Mechanisms to Headache. Oxford University Press 2007.
7. Neuroimmunology: The Immune System and Alzheimers, in the 2007 Progress Report on Brain Research, Dana Alliance for Brain Initiatives, Dana Press, New York ©2007.